First subject dosed with Nykode Therapeutics’ T cell focused SARS-CoV-2 vaccine candidate. This is part of the ongoing phase 1/2 two-arm clinical trial VB-D-01 designed to specifically address emerging variants of concern, including Omicron1
The T cell focused vaccine candidate (VB10.2210) encodes 96 clinically validated T cell epitopes spanning a total of eight SARS-CoV-2 proteins, including Spike. These Spike- and non-Spike T cell epitopes have been identified and validated by Adaptive Biotechnologies using their immune medicine platform
Initial analysis indicates that no epitopes outside the Spike are affected by the Omicron variant
OSLO, Norway, Dec. 28, 2021 (GLOBE NEWSWIRE) — Nykode Therapeutics AS (Euronext Growth (Oslo): NYKD), a clinical-stage biopharmaceutical company dedicated to the discovery and development of vaccines and novel immunotherapies, announced today the first subject has been dosed with its T cell focused next-generation SARS-CoV-2 vaccine candidate in its VB-D-01 Phase 1/2 trial (NCT05069623). The T cell specific vaccine is designed to prime T cells, potentially generating a broad immune response against current and future variants. The VB-D-01 trial is a two-arm, open label, dose escalation and dose expansion study to evaluate the safety, reactogenicity and immunogenicity of both the T cell specific/VB10.2210 and the RBD/VB10.2129 vaccine candidates in healthy, previously vaccinated subjects.
Siri Torhaug, Chief Medical Officer of Nykode Therapeutics, commented: “The emergence of the Omicron variant highlights the paramount need for next-generation COVID vaccines designed to be minimally impacted by future variants of concern such as Omicron. Dosing the first subject with our T cell focused vaccine candidate in this second arm of our COVID-19 vaccine trial is a remarkable milestone. We are also very pleased with the speed at which this was achieved.”
Mikkel W. Pedersen, Chief Scientific Officer of Nykode Therapeutics, continued: “The role of the cellular immune response to SARS-CoV-2 mediated by T cells reflects untapped potential. It has been shown that virus specific T cell responses in vaccinated human subjects coincide with rapid protection and are associated with milder disease in COVID-19 patients. While current Spike-based vaccine approaches generate limited T cell responses and uncertain long-term protection, the emergence of SARS-COV-2 variants with a high number of mutations in the Spike protein …
Original Article: benzinga.com